Science:Pharmacokinetics and pharmacodynamics of five distinct.pdf

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Image title	DOI: https://doi.org/10.1093/jat/bkad088, Journal of Analytical Toxicology, 00, 00, Published 4 December 2023. Abstract: Urine drug screening by immunoassay is a common method to quickly identify drug exposures in the emergency setting and to detect unexpected drug exposures in a variety of patient care and occupational health settings. Although they provide rapid results, immunoassays are susceptible to cross-reactivity with other medications and metabolites. Herein we evaluate the performance of the Thermo Scientific DRI Amphetamines immunoassay for reactivity with trazodone, aripiprazole, atomoxetine, solriamfetol and relevant metabolites. Each of these compounds were spiked into drug-free urine across a range of concentrations and assessed for positivity on amphetamine screen. We demonstrate that the Thermo Scientific DRI assay is susceptible to interferences from m-chlorophenylpiperazine (mCPP), the main metabolite of trazodone, and solriamfetol. Characterization of assay-specific interferences in toxicology screening is instrumental for accurate interpretation of toxicology results, evaluation of patients in emergent settings and supporting patient care.
Author	Ashley R. RackowClaire E. Knezevic
File change date and time	02:00, 4 December 2025
Date and time of digitizing	00:25, 24 February 2024
Date metadata was last modified	02:00, 4 December 2025
Software used	LuaLaTeX with hyperref package
Short title	Solriamfetol and m-chlorophenylpiperazine cause false positive amphetamine results on urine drug screening
Conversion program	LuaLaTeX; modified using iTextSharp.LGPLv2.Core 3.7.4.0
Encrypted	no
Page size	595.276 x 782.362 pts
Version of PDF format	1.6